circRNA basic information
circBase ID: hsa_circ_0001648
Name: hsa_circ_Utrn
Synonym: circRNA_0191
Host Gene: Utrn
Genomic location(hg19): chr6:145103057-145124283:+
Genomic location(hg38): chr6:144781921-144803147:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005203
MONDO name: ischemia reperfusion injury
Disease details: myocardial ischemia/reperfusion injury
Disease DO ID:
 -
Disease MeSH ID:
 D015427
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

adult mouse cardiomyocytes; mouse hearts; left ventricular samples; serum
Cell lines:

H9 human embryonic stem cell-induced cardiomyocytes (hESC-CMs); AC16 cardiomyocytes; HUVECs
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: PP5, SF3B1
Associated microRNA: -
Biological function: Required for exercise-induced physiological cardiac hypertrophy; protects against myocardial ischemia/reperfusion-induced acute injury and pathological cardiac remodeling; promotes cardiomyocyte growth and survival; attenuates cardiomyocyte apoptosis, cardiac dysfunction, and fibrosis.
Molecular mechanism: circUtrn directly binds PP5 and promotes PP5 degradation through the ubiquitin-proteasome system, resulting in activation of MAPK/ERK signaling; SF3B1 acts as an upstream regulator of circUtrn.
Biological pathway or process:

MAPK (promotes); ERK (promotes); apoptosis (inhibits); proliferation (promotes); cell cycle (promotes); fibrosis (inhibits); ubiquitination (promotes); other pathway/process (promotes)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Transfection; EdU Staining; TUNEL; IF (Immunofluorescence); Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Serum circUtrn was significantly increased in long-term exercise training adult men and may act as a new serum biomarker for prognosis among several cardiac diseases; circUtrn elevation may hold therapeutic promise in I/R injury patients.
Description:

circUtrn is an exercise-induced, conserved circRNA derived from Utrn that is downregulated in myocardial ischemia/reperfusion injury models. It promotes physiological cardiac hypertrophy and cardiomyocyte survival, while its overexpression protects against acute I/R injury and pathological cardiac remodeling. Mechanistically, circUtrn binds PP5, promotes PP5 ubiquitin-proteasome-dependent degradation, and activates MAPK/ERK signaling; SF3B1 functions as an upstream regulator.
Confidence score:

0.8543
Other information
Title:

Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury.

Journal: Cardiovascular research
Published: 2023
PubMed ID: 37897547
Study type:

combined biological and clinical study
Data availability: BioProject ID PRJNA801905; https://dataview.ncbi.nlm.nih.gov/object/PRJNA801905?reviewer=rv07nhirb8emtb7bh7m84h47
Code availability: -