circRNA basic information
circBase ID: hsa_circ_0000291
Name: hsa_circ_CD44
Synonym: -
Host Gene: CD44
Genomic location(hg19): chr11:35163017-35163328:+
Genomic location(hg38): chr11:35141470-35141781:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; adjacent normal tissues; mouse tumor tissues; lung tissue
Cell lines:

MGC-803; BGC823; SGC-7901; MKN-28; GES-1; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ITGB1
Associated microRNA: miR-183
Biological function: Promotes gastric cancer cell proliferation and migration/metastasis; its silencing suppresses tumor growth and metastasis in vitro and in vivo.
Molecular mechanism: Acts as a miR-183 sponge to regulate ITGB1 expression (ceRNA-like mechanism), thereby affecting proliferation and migration/metastasis.
Biological pathway or process:

proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
Validation methods:

RT-qPCR; FISH / smFISH; Bioinformatics Analysis; Luciferase Reporter Assay; Western Blot; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model
Clinical significance:

Potential biomarker and therapy target for gastric cancer diagnosis and treatment.
Description:

hsa_circ_0000291 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation and metastasis/migration. Mechanistically, it sponges miR-183 to increase ITGB1 expression, and knockdown of hsa_circ_0000291 suppresses tumor growth and metastasis in vitro and in nude-mouse xenograft models.
Confidence score:

0.5997
Other information
Title:

Downregulated Circular RNA hsa_circ_0000291 Suppresses Migration And Proliferation Of Gastric Cancer Via Targeting The miR-183/ITGB1 Axis.

Journal: Cancer management and research
Published: 2019
PubMed ID: 31814763
Study type:

combined biological and clinical study
Data availability: All data analyzed and generated in this research report are enclosed in the article.
Code availability: -