circRNA basic information
circBase ID: hsa_circ_0001141
Name: hsa_circ_ITCH
Synonym: cir-ITCH
Host Gene: ITCH
Genomic location(hg19): chr20:33001547-33037285:+
Genomic location(hg38): chr20:34413741-34449480:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary prostate cancer tissues; matched adjacent nontumor tissue samples
Cell lines:

LNCaP; PC-3; RWPE-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: beta-catenin, AKT, p-AKT, mTOR, p-mTOR
Associated microRNA: miR-17 / hsa-miR-17-5p
Biological function: Inhibits proliferation/viability, migration, and invasion of prostate cancer cells (tumor-suppressive role).
Molecular mechanism: Reciprocal inhibition with miR-17 and suppression of Wnt/beta-catenin and PI3K/AKT/mTOR pathway activity (reduced beta-catenin, p-AKT, p-mTOR) upon cir-ITCH overexpression; proposed miR-17 sponging.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); Wnt/beta-catenin (inhibits); PI3K/AKT/mTOR (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential therapeutic target for prostate cancer, especially castration-resistant prostate cancer.
Description:

cir-ITCH (hsa_circ_0001141) is down-regulated in prostate cancer tissues and cell lines. Its overexpression suppresses PCa cell viability/proliferation, migration and invasion, and it negatively interacts with miR-17 while inhibiting Wnt/beta-catenin and PI3K/AKT/mTOR signaling activity, suggesting therapeutic potential for CRPC.
Confidence score:

0.5732
Other information
Title:

Circular RNA cir-ITCH Is a Potential Therapeutic Target for the Treatment of Castration-Resistant Prostate Cancer.

Journal: BioMed research international
Published: 2020
PubMed ID: 32904490
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -