| Expression pattern: |
DS |
| Associated gene: |
CXCR4 |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker for lymph node metastasis in lung adenocarcinoma |
| Molecular mechanism: |
Not validated; negatively correlates with CXCR4 expression |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Plasma exo-hsa_circRNA_0056616 distinguishes lung adenocarcinoma patients with or without lymph node metastasis (AUC 0.812; cutoff 0.394; sensitivity 0.792; specificity 0.810). |
| Description: |
This study reports exosome-associated hsa_circRNA_0056616 as a plasma biomarker linked to lymph node metastasis status in lung adenocarcinoma, with ROC AUC 0.812. It is also modulated in CXCR4-knockdown LUAD cells/exosomes and shows correlation with CXCR4, but downstream miRNA/mRNA targets were not validated. |
| Confidence score: |
0.6238 |