| Expression pattern: |
UP |
| Associated gene: |
HOXA10 |
| Associated microRNA: |
miR-143-3p |
| Biological function: |
Promotes LUAD cell proliferation, migration, invasion, tumor growth and metastasis; inhibits apoptosis. |
| Molecular mechanism: |
circCSNK1G3 acts as a miR-143-3p sponge to suppress miR-143-3p and induce HOXA10 signaling, thereby promoting LUAD progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circCSNK1G3 expression was related to pathologic stage, tumor size and lymph node metastasis, suggesting potential prognostic value in LUAD. |
| Description: |
circCSNK1G3 (hsa_circ_0001522) is up-regulated in LUAD tissues and cell lines and functions as an oncogenic circRNA. It is predominantly cytoplasmic and promotes LUAD proliferation, migration, invasion, metastasis and xenograft tumor growth by sponging hsa-miR-143-3p and enhancing HOXA10 signaling. Its expression is associated with pathologic stage, tumor size and lymph node metastasis. |
| Confidence score: |
0.8399 |