| Expression pattern: |
UP |
| Associated gene: |
DTYMK, DAP3, STMN1 |
| Associated microRNA: |
hsa-miR-1343-3p |
| Biological function: |
promotes cell growth and metastasis |
| Molecular mechanism: |
acts as a miRNA sponge for hsa-miR-1343-3p to regulate downstream target genes (DTYMK, DAP3, STMN1) in a ceRNA network |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Microarray; RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Wound Healing Assay; FISH / smFISH; Sanger Sequencing; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis; Western Blot |
| Clinical significance: |
potential prognostic biomarker for HCC; targeting hsa_circ_0002003/hsa-miR-1343-3p/STMN1 axis may be a therapeutic strategy |
| Description: |
hsa_circ_0002003 is up-regulated in HCC and promotes proliferation, migration/invasion and metastasis-related phenotypes in liver cancer cells. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging hsa-miR-1343-3p to affect downstream targets including STMN1 (and also DTYMK, DAP3), with the proposed key axis hsa_circ_0002003/hsa-miR-1343-3p/STMN1. |
| Confidence score: |
0.798 |