| Expression pattern: |
DN |
| Associated gene: |
TGFBR2 |
| Associated microRNA: |
miR-9-5p |
| Biological function: |
Suppresses bladder cancer cell proliferation, migration, invasion and metastasis (tumor suppressor role). |
| Molecular mechanism: |
ceRNA mechanism: circ-FOXO3 sponges miR-9-5p to regulate TGFBR2 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
Low circ-FOXO3 expression correlated with poor survival rates in BC patients; circ-FOXO3 may serve as a prognostic biomarker. |
| Description: |
circ-FOXO3 is down-regulated in bladder cancer tissues and functions as a tumor suppressor. It inhibits bladder cancer cell proliferation, migration and invasion by sponging miR-9-5p and regulating TGFBR2. Low circ-FOXO3 expression is associated with poorer patient survival, suggesting prognostic potential. |
| Confidence score: |
0.7325 |