| Expression pattern: |
UP |
| Associated gene: |
MMP-2, MMP-9, VEGF |
| Associated microRNA: |
miR-140-3p |
| Biological function: |
Promotes CRC cell viability/proliferation, migration and invasion; enhances MMP-2/MMP-9/VEGF expression. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) binding miR-140-3p, leading to regulation of MMP-related markers (MMP-2, MMP-9) and VEGF. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Clinical Sample Validation; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
Potential biomarker/therapeutic target for CRC. |
| Description: |
circSMARCC1 is up-regulated in colorectal cancer tissues/cell lines and promotes proliferation, migration and invasion. Mechanistically, it sponges miR-140-3p and regulates MMP-related markers (MMP-2/MMP-9) and VEGF, forming a circSMARCC1/miR-140-3p/MMPs axis with potential biomarker/therapeutic relevance. |
| Confidence score: |
0.8119 |