circRNA basic information
circBase ID: -
Name: hsa_circ_TMCO3
Synonym: circRNA_101308
Host Gene: TMCO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CC tissues; matched paracancerous tissues
Cell lines:

SiHa; CaSki; HeLa
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-26a-5p, miR-196a-5p, miR-196b-5p, miR-335-3p, miR-1307-3p
Biological function: Suppresses cervical cancer cell proliferation, migration and invasion; inhibits tumor growth in vivo
Molecular mechanism: Sponges multiple miRNAs (identified by RNA pull-down and miRNA sequencing); downstream functional processes/pathways predicted by GO and KEGG analyses
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); TNF-kappaB (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; RNA Pull-Down; RNA-seq; Bioinformatics Analysis
Clinical significance:

Lower circRNA_101308 levels are associated with lymph node metastasis and deep myometrial invasion
Description:

circRNA_101308 (from TMCO3) is down-regulated in cervical cancer tissues and acts as a tumor suppressor by inhibiting proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges multiple miRNAs (miR-26a-5p, miR-196a-5p, miR-196b-5p, miR-335-3p, miR-1307-3p), with downstream pathways predicted by GO/KEGG enrichment.
Confidence score:

0.6815
Other information
Title:

The Regulatory Role of circRNA_101308 in Cervical Cancer and the Prediction of Its Mechanism.

Journal: Cancer management and research
Published: 2020
PubMed ID: 32606970
Study type:

combined biological and clinical study
Data availability: -
Code availability: -