| Expression pattern: |
DN |
| Associated gene: |
KLF9, Ago2 |
| Associated microRNA: |
miR-135a-5p, miR-135b-5p |
| Biological function: |
Suppresses CRC progression by inhibiting proliferation, cell-cycle progression, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-135a-5p/miR-135b-5p to regulate KLF9 expression. |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
CircNOL10 expression is associated with clinicopathological stages and lymphatic metastasis; higher circNOL10 expression indicates longer survival time in CRC patients. |
| Description: |
CircNOL10 is down-regulated in colorectal cancer and higher expression correlates with longer survival. Functionally, circNOL10 suppresses CRC cell proliferation, cell-cycle progression, migration and invasion, and inhibits xenograft tumor growth by sponging miR-135a-5p/miR-135b-5p to relieve repression of KLF9. |
| Confidence score: |
0.8324 |