circRNA basic information
circBase ID: hsa_circ_0004104
Name: hsa_circ_SPARC
Synonym: circ_0004104
Host Gene: SPARC
Genomic location(hg19): chr5:151043647-151049345:-
Genomic location(hg38): chr5:151664086-151669784:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tumor tissues; adjacent normal tissues
Cell lines:

HGC-27; AGS; GES-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: RNF2
Associated microRNA: miR-539-3p
Biological function: circ_0004104 promotes gastric cancer progression; circ_0004104 knockdown represses proliferation, migration, invasion, metastasis, glutaminolysis, and tumor growth in vivo.
Molecular mechanism: circ_0004104 acts as a sponge for miR-539-3p and positively regulates RNF2 expression to promote gastric cancer progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glutaminolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circ_0004104 expression was associated with TNM stages, lymph metastasis, tumor size, and poor prognosis; circ_0004104 might be a potential therapeutic target for GC.
Description:

circ_0004104 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with advanced clinical features and poor prognosis. Functionally, circ_0004104 promotes proliferation, migration, invasion, glutaminolysis, and in vivo tumor growth. Mechanistically, it sponges miR-539-3p to positively regulate RNF2 expression, forming a circ_0004104/miR-539-3p/RNF2 axis.
Confidence score:

0.7646
Other information
Title:

Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis.

Journal: Digestive diseases and sciences
Published: 2021
PubMed ID: 33449226
Study type:

combined biological and clinical study
Data availability: GSE141977; TCGA COAD dataset
Code availability: -