circRNA basic information
circBase ID: hsa_circ_0010023
Name: hsa_circ_DHRS3
Synonym: chr1: 12578718-12579412-
Host Gene: DHRS3
Genomic location(hg19): chr1:12638745-12639440:-
Genomic location(hg38): chr1:12578717-12579412:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: Papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissue; neighboring non-tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: potential diagnostic biomarker for PTC
Molecular mechanism: predicted ceRNA network (circRNA-miRNA-mRNA) involvement; not experimentally validated
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

effective diagnostic indicator; potential biomarker for the diagnosis of PTC
Description:

chr1: 12578718-12579412- (hsa_circ_0010023; host gene DHRS3) is up-regulated in papillary thyroid carcinoma and has diagnostic potential supported by RT-qPCR validation and ROC analyses in two clinical cohorts. Its downstream mechanism is not experimentally validated and was only explored via predicted ceRNA network analysis.
Confidence score:

0.5047
Other information
Title:

Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.

Journal: OncoTargets and therapy
Published: 2021
PubMed ID: 34188490
Study type:

combined biological and clinical study
Data availability: GSE171011
Code availability: -