| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-9 |
| Biological function: |
Potential blood-based diagnostic biomarker (AUC > 0.950, sensitivity/specificity > 90%); negatively associated with age at time of blood collection. |
| Molecular mechanism: |
Predicted miRNA sponge via binding sites for hsa-miR-9; functional association proposed but not experimentally validated. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
AUC over 0.950 with sensitivity and specificity over 90% for ALS diagnosis; negatively associated with age at time of blood collection. |
| Description: |
hsa_circ_0023919 (PICALM-derived) is down-regulated in ALS blood leukocytes/PBMCs and shows strong diagnostic potential (AUC > 0.95). It is predicted to contain binding sites for hsa-miR-9, suggesting a possible miRNA-sponge relationship, but this mechanism is not functionally validated in the study. |
| Confidence score: |
0.5963 |