circRNA basic information
circBase ID: hsa_circ_0001246
Name: hsa_circ_ATXN10
Synonym: circATXN10
Host Gene: ATXN10
Genomic location(hg19): chr22:46096161-46136418:+
Genomic location(hg38): chr22:45700281-45740538:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

malignant tissue samples; adjacent normal tissue samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker to discriminate malignant vs adjacent normal prostate tissue; evaluated as a biomarker for biochemical recurrence prediction but did not add independent value compared with linear RNAs.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Cohort Study
Clinical significance:

Discriminates malignant vs adjacent normal prostate tissue (AUC 0.801); circATXN10 + linSTIL combination improved discrimination (AUC 0.892).
Description:

circATXN10 is down-regulated in prostate cancer tissue and serves as a diagnostic tissue biomarker for distinguishing malignant from adjacent normal prostate tissue. It was evaluated for BCR prediction but did not contribute independently when linear RNAs were considered.
Confidence score:

0.6663
Other information
Title:

Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.

Journal: International journal of molecular sciences
Published: 2020
PubMed ID: 33105568
Study type:

combined biological and clinical study
Data availability: Supplementary Microarray Data File.xlsx; TCGA-PRAD
Code availability: -