| Expression pattern: |
DN |
| Associated gene: |
VANGL2, CTNNB1, vimentin |
| Associated microRNA: |
miR-1270 |
| Biological function: |
Inhibits NSCLC cell invasion and migration. |
| Molecular mechanism: |
May act through a ceRNA-like network involving miR-1270 and VANGL2, influencing Wnt/beta-catenin signaling (via VANGL2). |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); Wnt/beta-catenin (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Bioinformatics Analysis; RNA-seq; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Transfection; Wound Healing Assay; Transwell Assay |
| Clinical significance: |
Low circ-IGF1R expression was associated with larger tumors (T2/T3/T4) and lymph node metastasis (N1/N2/N3); suggested to indicate poor prognosis. |
| Description: |
circ-IGF1R (hsa_circ_0005035) is down-regulated in NSCLC tissues and cell lines and its overexpression suppresses NSCLC cell migration and invasion. Mechanistically, it is proposed to inhibit Wnt/beta-catenin signaling via a circ-IGF1R/miR-1270/VANGL2 regulatory axis. |
| Confidence score: |
0.7165 |