| Expression pattern: |
DN |
| Associated gene: |
PTEN, E-cadherin, p21, TIMP3, MAPK10, QKI |
| Associated microRNA: |
miR-21 |
| Biological function: |
Acts as a tumor suppressor in NSCLC; inhibits NSCLC cell proliferation, invasion, tumor growth and lung metastasis. |
| Molecular mechanism: |
circ-SLC7A6 functions as a cytoplasmic miR-21 sponge, suppressing miR-21 and elevating miR-21 downstream tumor suppressors including PTEN, E-cadherin, p21, TIMP3, MAPK10 and QKI; QKI binds introns flanking circ-SLC7A6 and facilitates circ-SLC7A6 production. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ-SLC7A6 was associated with larger tumor size, lymph node metastasis, advanced clinical stage and adverse outcome; patients with high circ-SLC7A6 had longer overall and disease-free survival time, implying prognostic indicator potential in NSCLC. |
| Description: |
circ-SLC7A6 is downregulated in NSCLC and low expression is associated with aggressive clinicopathological features and worse survival. Functionally, circ-SLC7A6 suppresses NSCLC proliferation, invasion, tumor growth and lung metastasis by sponging oncogenic miR-21 and increasing multiple miR-21 downstream tumor suppressors. QKI is also implicated in a positive regulatory loop by binding introns flanking circ-SLC7A6 and facilitating its production. |
| Confidence score: |
0.8769 |