| Expression pattern: |
UP |
| Associated gene: |
POLD4 |
| Associated microRNA: |
miR-1200 |
| Biological function: |
promotes cisplatin (CDDP) resistance; increases cell viability/proliferation and decreases apoptosis under CDDP treatment |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circ_0026359 binds and negatively regulates miR-1200, releasing repression on POLD4, thereby promoting CDDP resistance |
| Biological pathway or process: |
chemoresistance (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Survival Analysis; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High circ_0026359 expression was associated with low OS and RFS rates in gastric cancer patients. |
| Description: |
circ_0026359 is up-regulated in gastric cancer, especially in CDDP-resistant tissues/cells, and high expression predicts worse OS/RFS. It mainly localizes to the cytoplasm and promotes cisplatin resistance by sponging miR-1200, thereby increasing POLD4 expression; miR-1200/POLD4 mediates this effect. |
| Confidence score: |
0.7967 |