circRNA basic information
circBase ID: hsa_circ_0007841
Name: hsa_circ_SEC61A1
Synonym: circ_0007841
Host Gene: SEC61A1
Genomic location(hg19): chr3:127778944-127779504:+
Genomic location(hg38): chr3:128060101-128060661:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009693
MONDO name: plasma cell myeloma
Disease details: multiple myeloma
Disease DO ID:
 9538
Disease MeSH ID:
 D009101
Disease NCIt ID:
 C3242
Disease ICD11 ID:
 1582389689; 526287100
Disease OMIM ID:
 254500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

U266; RPMI-8226; U266R; 8226R; U266P; 8226P
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ABCG2
Associated microRNA: -
Biological function: promotes acquired chemotherapy resistance (doxorubicin resistance) in multiple myeloma cells
Molecular mechanism: Upregulates ABCG2 mRNA and protein levels; ABCG2 mediates circRNA-induced chemoresistance (specific upstream mechanism such as miRNA sponge not investigated).
Biological pathway or process:

drug resistance (promotes); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Western Blot
Clinical significance:

-
Description:

In doxorubicin-resistant multiple myeloma cell models (U266R and 8226R), hsa_circ_0007841 is up-regulated and promotes chemoresistance. Knockdown of hsa_circ_0007841 reduces IC50 and decreases ABCG2 mRNA/protein, while overexpression increases ABCG2 and resistance; ABCG2 inhibition blocks the resistance phenotype.
Confidence score:

0.3957
Other information
Title:

Hsa_Circ_0007841 Enhances Multiple Myeloma Chemotherapy Resistance Through Upregulating ABCG2.

Journal: Technology in cancer research & treatment
Published: 2020
PubMed ID: 32552614
Study type:

biological research
Data availability: Supplemental material for this article is available online.
Code availability: -