| Expression pattern: |
DN |
| Associated gene: |
FOXO3a, NLRP3, caspase-1, IL-1beta, IL-18 |
| Associated microRNA: |
miR-421 |
| Biological function: |
Promotes ischemic muscle repair, stimulates myoblast proliferation, and inhibits ischemia/inflammasome-induced pyroptosis and inflammatory cytokine release. |
| Molecular mechanism: |
Exosome-delivered circHIPK3 sponges miR-421 to de-repress FOXO3a, leading to suppression of NLRP3/caspase-1 inflammasome activation and reduced IL-1beta/IL-18 release. |
| Biological pathway or process: |
pyroptosis (inhibits); inflammation (inhibits); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; EdU Staining; Western Blot; ELISA; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circHIPK3 is decreased in ischemic hindlimb muscle and can be replenished by UMSC-derived exosomes. Exosomal circHIPK3 sponges miR-421 to increase FOXO3a, thereby inhibiting NLRP3/caspase-1 inflammasome activation, reducing IL-1beta/IL-18 release and pyroptosis, and improving muscle repair and function. |
| Confidence score: |
0.7164 |