| Expression pattern: |
UP |
| Associated gene: |
ABCB1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes chemoresistance to doxorubicin and cisplatin; supports cell proliferation under drug treatment. |
| Molecular mechanism: |
CircPVT1 enhances chemoresistance by positively regulating ABCB1 expression (mechanism not fully determined). |
| Biological pathway or process: |
drug resistance (promotes); proliferation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Transfection; CCK8; Colony Formation Assay; Western Blot |
| Clinical significance: |
High circPVT1 is associated with shorter overall survival and shows diagnostic value in serum (AUC 0.871), performing better than ALP. |
| Description: |
circPVT1 is up-regulated in osteosarcoma tissues/serum and is higher in chemoresistant and metastatic groups. Functionally, circPVT1 knockdown reduces doxorubicin/cisplatin resistance and decreases ABCB1 mRNA/protein, supporting circPVT1 as a diagnostic/prognostic biomarker and a chemoresistance-related regulator in OS. |
| Confidence score: |
0.6527 |