circRNA basic information
circBase ID: hsa_circ_0072309
Name: hsa_circ_LIFR
Synonym: -
Host Gene: LIFR
Genomic location(hg19): chr5:38523520-38530768:-
Genomic location(hg38): chr5:38523418-38530666:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; GBM; adjacent non-tumor brain; non-tumor brain tissues; orthotopic tumour sections
Cell lines:

U251; U87; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: HSP27
Associated microRNA: -
Biological function: Inhibits GBM cell proliferation and invasion, affects cytoskeleton organization, and suppresses tumor growth in an intracranial xenograft model.
Molecular mechanism: hsa_circ_0072309 inhibits GBM proliferation and invasion by downregulating HSP27; the exact upstream mechanism of HSP27 downregulation was not clarified.
Biological pathway or process:

proliferation (inhibits); invasion (inhibits); migration (inhibits); EMT (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model
Clinical significance:

hsa_circ_0072309 may act as a potential therapeutic target for GBM comprehensive treatment.
Description:

hsa_circ_0072309 is downregulated in GBM/glioma tissues compared with non-tumor brain tissues. Functionally, it suppresses GBM cell proliferation and invasion in vitro and reduces tumor growth in an intracranial U87 xenograft model. Mechanistically, the study links its tumor-suppressive effects to downregulation of HSP27 and changes in cytoskeleton/EMT-related markers.
Confidence score:

0.622
Other information
Title:

Hsa_circ_0072309 inhibits proliferation and invasion of glioblastoma.

Journal: Pathology, research and practice
Published: 2021
PubMed ID: 33862563
Study type:

combined biological and clinical study
Data availability: TCGA_GBMLGG; Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.prp.2021.153433.
Code availability: -