circRNA basic information
circBase ID: -
Name: hsa_circ_FADS2
Synonym: circFADS2
Host Gene: FADS2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005229
MONDO name: bacterial infectious disease with sepsis
Disease details: sepsis
Disease DO ID:
 0040085
Disease MeSH ID:
 D016470
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

HBEpCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-15a-5p
Biological function: suppresses LPS-induced lung cell apoptosis
Molecular mechanism: inhibits the maturation of miR-15a-5p
Biological pathway or process:

apoptosis (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Annexin V/PI Flow Cytometry
Clinical significance:

-
Description:

circFADS2 is up-regulated in sepsis plasma and is induced by LPS in HBEpCs. Its overexpression suppresses LPS-induced apoptosis, at least partly by inhibiting the maturation (and thus reducing the level) of mature miR-15a-5p.
Confidence score:

0.5218
Other information
Title:

Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p.

Journal: BMC immunology
Published: 2021
PubMed ID: 33980140
Study type:

combined biological and clinical study
Data availability: The data supporting the findings of this study are available on request from the corresponding author. The data are not publicly available due to containing information that could compromise the privacy of research participants.
Code availability: -