| Expression pattern: |
UP |
| Associated gene: |
SOX4, Ago2 |
| Associated microRNA: |
miR-211-5p |
| Biological function: |
promotes proliferation and invasion; promotes tumor growth |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0008285 sponges miR-211-5p to release SOX4 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
High hsa_circ_008285 expression was correlated with advanced FIGO stage, and lymph node metastasis in CC patients. |
| Description: |
hsa_circ_0008285 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes CC cell proliferation and invasion and enhances tumor growth by sponging miR-211-5p, thereby relieving repression of SOX4. |
| Confidence score: |
0.7855 |