| Expression pattern: |
UP |
| Associated gene: |
RHEB, Ago2, EIF5, mTORC1 |
| Associated microRNA: |
miR-1301-3p |
| Biological function: |
promotes proliferation and viability, enhances colony formation, inhibits apoptosis in cervical cancer cells |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-1301-3p to upregulate RHEB, thereby activating RHEB-dependent mTOR signaling |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); mTOR signaling (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; TUNEL; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circMYLK is up-regulated in cervical cancer cell lines and promotes malignant growth by enhancing proliferation/viability and inhibiting apoptosis. Mechanistically, circMYLK mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-1301-3p, thereby upregulating RHEB and activating mTOR signaling. |
| Confidence score: |
0.7918 |