| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-2682-3p / hsa-miR-2682 |
| Biological function: |
Promotes TNBC progression by enhancing proliferation, colony formation and migration; knockdown suppresses these phenotypes. |
| Molecular mechanism: |
Acts as a miRNA sponge for hsa-miR-2682, supported by luciferase reporter assay and MS2-based RIP; miR-2682 inhibition rescues the effects of hsa_circ_0131242 knockdown. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High expression of hsa_circ_0131242 was positively correlated with advanced tumor stages and poorer clinical features, and patients with high hsa_circ_0131242 level had a poorer overall survival. |
| Description: |
hsa_circ_0131242 is up-regulated in TNBC tissues and breast cancer cell lines and promotes malignant phenotypes (proliferation, colony formation, migration). Mechanistically, it functions as a ceRNA by sponging hsa-miR-2682, and high expression is associated with advanced stage and worse overall survival. |
| Confidence score: |
0.8343 |