circRNA basic information
circBase ID: hsa_circ_0001013
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:61339656-61345251:+
Genomic location(hg38): chr2:61112521-61118116:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: Gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; paracancer tissues; normal gastric samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FBN1, FN1, THBS1, AJUBA, ASPN, CAMK2N1, COL5A1, ZAK, PDPN, PLPPR4, PRRX1, THBS2, WISP1, FGD6, MEST, PTPN12, TPM4
Associated microRNA: miR-182-5p, hsa-miR-145-5p, miR-758-3p
Biological function: May regulate ECM and adhesion and contribute to adhesion and metastasis in GC.
Molecular mechanism: ceRNA (miRNA sponge) mechanism via MRE competition (e.g., miR-182-5p; miR-145-5p; miR-758-3p) to regulate target genes such as FBN1 and FN1.
Biological pathway or process:

PI3K/AKT (other); ceRNA regulation (other); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identified hsa_circ_0001013 as up-regulated in gastric cancer based on GEO circRNA microarrays. Bioinformatics prediction suggests it may function as a ceRNA (e.g., sponging miR-182-5p/miR-145-5p/miR-758-3p) to regulate ECM/adhesion-related genes such as FBN1 and FN1, potentially influencing adhesion and metastasis and relating to PI3K-Akt and ECM-receptor interaction.
Confidence score:

0.1768
Other information
Title:

Bioinformatics Analysis of Key Genes and circRNA-miRNA-mRNA Regulatory Network in Gastric Cancer.

Journal: BioMed research international
Published: 2020
PubMed ID: 32908877
Study type:

bioinformatics study
Data availability: GSE83521; GSE93541; GSE13911; GSE79973; GSE118916
Code availability: -