| Expression pattern: |
DN |
| Associated gene: |
APP |
| Associated microRNA: |
miR-4793-5p |
| Biological function: |
Promotes cardiomyocyte proliferation and improves cardiac function after myocardial infarction; supports myocardial regeneration and repair. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-4793-5p, thereby modulating APP expression. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Luciferase Reporter Assay; Western Blot; Transfection; EdU Staining; IF (Immunofluorescence); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In a mouse myocardial infarction model and hypoxia-treated cardiomyocytes, circCDYL is downregulated. Functional assays show circCDYL promotes cardiomyocyte proliferation and improves post-MI cardiac function by sponging miR-4793-5p to regulate APP. |
| Confidence score: |
0.6945 |