circRNA basic information
circBase ID: hsa_circ_0004370
Name: hsa_circ_PRRX1
Synonym: -
Host Gene: PRRX1
Genomic location(hg19): chr1:170688866-170695542:+
Genomic location(hg38): chr1:170719725-170726401:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007576
MONDO name: esophageal cancer
Disease details: esophageal cancer
Disease DO ID:
 5041
Disease MeSH ID:
 -
Disease NCIt ID:
 C7478
Disease ICD11 ID:
 669033105
Disease OMIM ID:
 133239
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

Eca-109; TE-1; KYSE-150; Het-1A; HEK293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: LASP1, Ago2
Associated microRNA: miR-1294
Biological function: Promotes proliferation and invasion and inhibits apoptosis in esophageal cancer cells.
Molecular mechanism: Acts as a miRNA sponge for miR-1294 to increase LASP1 expression (ceRNA-like regulation).
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

High expression of hsa_circ_0004370 was associated with the tumor size in EC.
Description:

hsa_circ_0004370 is up-regulated in esophageal cancer tissues and cell lines and promotes malignant behaviors (proliferation and invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-1294 to relieve repression of LASP1, forming the hsa_circ_0004370/miR-1294/LASP1 axis.
Confidence score:

0.7032
Other information
Title:

Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway.

Journal: Bioscience reports
Published: 2019
PubMed ID: 30988074
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the study are available from the corresponding author on reasonable request.
Code availability: -