| Expression pattern: |
UP |
| Associated gene: |
platelets, neutrophils, WBC |
| Associated microRNA: |
- |
| Biological function: |
Acts as a circulating biomarker/predictor for stroke associated infection in acute ischemic stroke patients; associated with neutrophil counts and platelet enrichment. |
| Molecular mechanism: |
Mechanism not experimentally established; discussion suggests possible host-gene/mitophagy-related involvement. |
| Biological pathway or process: |
immune regulation (other); mitochondrial function (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Elevated plasma circFUNDC1 predicts occurrence of SAI in AIS patients; improves ROC/AUC when added to clinical risk model; Kaplan-Meier curves showed significant differences for SAI occurrence and 90-day survival between high vs low circFUNDC1 groups. |
| Description: |
In plasma from AIS patients, circFUNDC1 is higher in those who develop stroke-associated infection and provides modest predictive value (ROC/AUC) that slightly improves a clinical risk model. circFUNDC1 levels correlate with platelet counts and neutrophil counts, suggesting these cells may contribute to elevated circulating circFUNDC1 in SAI. |
| Confidence score: |
0.5339 |