| Expression pattern: |
UP |
| Associated gene: |
ABCC1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration and invasion, and inhibits apoptosis of pancreatic cancer cells. |
| Molecular mechanism: |
Mechanism not investigated in this study; only stability (RNase R resistance) and phenotypic effects after knockdown were tested. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Survival Analysis; Transfection; MTT; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis |
| Clinical significance: |
Upregulated in tissues and plasma of PC patients; high level correlates with lymphatic metastasis, clinical stage, and venous invasion; diagnostic value with AUC 0.716; independent prognostic indicator for overall survival and high expression predicts poor prognosis. |
| Description: |
circ_001569 is upregulated in pancreatic cancer tissues and patient plasma and is associated with aggressive clinicopathological features. High circ_001569 predicts poorer overall survival and shows moderate diagnostic performance in plasma. Functionally, circ_001569 promotes malignant phenotypes (proliferation, migration, invasion) and inhibits apoptosis in PC cell lines, while its molecular mechanism was not defined. |
| Confidence score: |
0.7617 |