| Expression pattern: |
UP |
| Associated gene: |
CCNA2 |
| Associated microRNA: |
miR-545 |
| Biological function: |
promoted proliferation of osteosarcoma cells |
| Molecular mechanism: |
acts as a sponge for miR-545 to elevate CCNA2 expression |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; EdU Staining; Western Blot |
| Clinical significance: |
elevated level linked to poor prognosis; high-expression group had lower overall survival rate; may serve as a prognostic marker |
| Description: |
hsa_circ_0003732 is up-regulated in osteosarcoma tissues/cells and high expression is associated with poorer overall survival. Functionally, it promotes osteosarcoma cell proliferation by sponging miR-545 and thereby increasing CCNA2 expression, affecting cell-cycle progression. |
| Confidence score: |
0.7846 |