| Expression pattern: |
UP |
| Associated gene: |
FOXK1, Ago2 |
| Associated microRNA: |
miR-191-5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration, invasion, growth and metastasis, and inhibits apoptosis; knockdown suppresses proliferation, migration and invasion and promotes apoptosis. |
| Molecular mechanism: |
circ-ATAD1 functions as a ceRNA that absorbs miR-191-5p to upregulate FOXK1 expression, thereby promoting NSCLC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; FISH / smFISH; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-ATAD1 expression is associated with higher clinical stage, lymphatic metastasis, shorter survival time, and poor prognosis; circ-ATAD1 may be a potential prognostic biomarker for NSCLC. |
| Description: |
circ-ATAD1 is up-regulated in NSCLC tissues and cells and its high expression is associated with advanced disease features and poor survival. Functionally, it promotes proliferation, migration, invasion, growth and metastasis of NSCLC cells while suppressing apoptosis. Mechanistically, circ-ATAD1 acts as a ceRNA for miR-191-5p to increase FOXK1 expression. |
| Confidence score: |
0.7759 |