| Expression pattern: |
UP |
| Associated gene: |
ABCB1 mRNA |
| Associated microRNA: |
miR-34b-3p, miR-29c-3p, miR-877-3p |
| Biological function: |
contributes to docetaxel resistance; may act as a ceRNA/miRNA sponge leading to upregulation of ABCB1 expression |
| Molecular mechanism: |
ceRNA mechanism (miRNA sponge) affecting ABCB1 expression; pathway-level association with PI3K-Akt and AGE-RAGE signaling based on target enrichment of eligible miRNAs |
| Biological pathway or process: |
ceRNA regulation (promotes); PI3K/AKT (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Sanger Sequencing; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circABCB1 is strongly up-regulated in docetaxel-resistant breast cancer cell lines. It is proposed to act as a ceRNA/miRNA sponge (e.g., miR-877-3p) and thereby promote ABCB1 expression, contributing to docetaxel resistance, with pathway associations inferred from enrichment (PI3K-Akt and AGE-RAGE). |
| Confidence score: |
0.4761 |