| Expression pattern: |
UP |
| Associated gene: |
TFAP2B |
| Associated microRNA: |
miR-143 |
| Biological function: |
CircUBAP2 promotes prostate cancer cell viability, proliferation, migration, invasion, metastasis, EMT and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
CircUBAP2 acts as a competing endogenous RNA that sponges miR-143, thereby enhancing TFAP2B expression to promote prostate cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
CircUBAP2 might be a promising therapeutic target for prostate cancer. |
| Description: |
CircUBAP2 is up-regulated in prostate cancer tissues and cells and functions as an oncogenic circRNA. Mechanistically, it sponges miR-143 to enhance TFAP2B expression, thereby promoting cell viability, migration, invasion, EMT and in vivo tumor growth while suppressing apoptosis. The study suggests circUBAP2 may be a therapeutic target in prostate cancer. |
| Confidence score: |
0.713 |