circRNA basic information
circBase ID: hsa_circ_0072305
Name: hsa_circ_LIFR
Synonym: -
Host Gene: LIFR
Genomic location(hg19): chr5:38496483-38530768:-
Genomic location(hg38): chr5:38496381-38530666:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumor tissues; healthy lung tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: DTL
Associated microRNA: hsa-miR-127-5p
Biological function: May be involved in the occurrence and development of NSCLC.
Molecular mechanism: Bioinformatically constructed circRNA-miRNA-mRNA network (putative ceRNA regulation) involving hsa-miR-127-5p and DTL.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

The hsa_circ_0072305/hsa-miR-127-5p/DTL network could also serve as a target for the early diagnosis and specific treatment of NSCLC.
Description:

This study bioinformatically identified hsa_circ_0072305 as down-regulated in NSCLC and highlighted a putative ceRNA axis hsa_circ_0072305-hsa-miR-127-5p-DTL. The authors suggest the network may contribute to NSCLC development and could be a diagnostic/therapeutic target, pending experimental validation.
Confidence score:

0.1768
Other information
Title:

Bioinformatics analysis of the circRNA-miRNA-mRNA network for non-small cell lung cancer.

Journal: The Journal of international medical research
Published: 2020
PubMed ID: 32527185
Study type:

bioinformatics study
Data availability: GSE112214; GSE102286; GSE101929
Code availability: -