| Expression pattern: |
UP |
| Associated gene: |
NOVA2 |
| Associated microRNA: |
miR-377-5p |
| Biological function: |
Promotes proliferation, migration, invasion/metastasis and tumor growth in NSCLC. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-377-5p, thereby upregulating NOVA2. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); cell cycle (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Microarray |
| Clinical significance: |
- |
| Description: |
circ_0072088 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes. Mechanistically, it sponges miR-377-5p to relieve repression of NOVA2, enhancing proliferation and metastatic traits and supporting tumor growth in xenografts. |
| Confidence score: |
0.78 |