| Expression pattern: |
UP |
| Associated gene: |
CTNNB1 (beta-catenin), beta-catenin, c-myc |
| Associated microRNA: |
miR-142, miR-568, miR-634 |
| Biological function: |
promotes proliferation, colony formation, migration, cell cycle progression and tumorigenicity; inhibits apoptosis |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-142, miR-568 and miR-634, thereby relieving repression of CTNNB1 (beta-catenin) and activating Wnt/beta-catenin pathway. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); cell cycle (promotes); Wnt/beta-catenin (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Luciferase Reporter Assay; RNA Pull-Down; ISH (In Situ Hybridization); Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circIFT80 represents a novel candidate for diagnosis and treatment in CRC (diagnostic marker claim limited by small sample size). |
| Description: |
circIFT80 is up-regulated in colorectal cancer tissues and cells and functions as an oncogenic circRNA. It sponges miR-142/miR-568/miR-634 to increase CTNNB1 (beta-catenin) expression, activating Wnt/beta-catenin signaling and promoting proliferation, cell-cycle progression, migration, and tumor growth while inhibiting apoptosis. |
| Confidence score: |
0.7741 |