| Expression pattern: |
UP |
| Associated gene: |
CISD2 |
| Associated microRNA: |
miR-335-5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration and glycolysis, and inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miR-335-5p sponge to upregulate CISD2 (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circSLC25A16 may serve as a novel biomarker for NSCLC treatment. |
| Description: |
circSLC25A16 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration and glycolysis while suppressing apoptosis. Mechanistically, it sponges miR-335-5p to increase CISD2 expression, thereby enhancing NSCLC progression and xenograft tumor growth. |
| Confidence score: |
0.8172 |