| Expression pattern: |
UP |
| Associated gene: |
HIF-1alpha, LDHA |
| Associated microRNA: |
miR-488-3p |
| Biological function: |
accelerated glycolysis and promoted proliferation; promoted in vivo tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circSLC25A16 sponges miR-488-3p to relieve repression of HIF-1alpha, which transcriptionally activates LDHA |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Western Blot; ChIP / ChIP-seq; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high-expression of circSLC25A16 was associated with unfavorable prognosis |
| Description: |
circSLC25A16 is up-regulated in NSCLC and promotes glycolysis and proliferation. It functions mainly in the cytoplasm as a miRNA sponge for miR-488-3p, thereby increasing HIF-1alpha and enhancing LDHA transcription, which supports tumor growth and is associated with poor prognosis. |
| Confidence score: |
0.8701 |