| Expression pattern: |
UP |
| Associated gene: |
ABL2 |
| Associated microRNA: |
miR-1179 |
| Biological function: |
Promotes cervical cancer cell proliferation and tumor growth, inhibits apoptosis, and acts as an oncogenic circRNA in cervical cancer. |
| Molecular mechanism: |
circ_0000263 functions as a miR-1179 sponge to positively regulate ABL2 expression, thereby promoting cervical cancer progression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High expression was related to clinical stage, tumor size and lymphoid node metastasis of CC patients; circ_0000263 might be a potential target for CC treatment. |
| Description: |
circ_0000263 is up-regulated in cervical cancer tissues and cells and is associated with more advanced clinical features. Functionally, circ_0000263 promotes proliferation and tumor growth while inhibiting apoptosis. Mechanistically, cytoplasmic circ_0000263 sponges miR-1179 to up-regulate ABL2, forming a circ_0000263/miR-1179/ABL2 oncogenic axis. |
| Confidence score: |
0.7373 |