| Expression pattern: |
UP |
| Associated gene: |
PIK3CA |
| Associated microRNA: |
miR-199a-3p |
| Biological function: |
Promotes proliferation and inhibits apoptosis of HCC cells; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge/decoy to deplete miR-199a-3p, thereby increasing PIK3CA expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
Circ-ZEB1 was upregulated in HCC and predicted a poor prognosis; suggested as a biomarker for diagnosis and treatment. |
| Description: |
Circ-ZEB1 is up-regulated in HCC and associated with poor prognosis. Functionally, circ-ZEB1 promotes HCC cell proliferation and suppresses apoptosis, and its knockdown inhibits xenograft tumor growth. Mechanistically, circ-ZEB1 binds and depletes miR-199a-3p, relieving repression of PIK3CA and increasing PIK3CA mRNA/protein expression. |
| Confidence score: |
0.798 |