| Expression pattern: |
DN |
| Associated gene: |
PAX5 |
| Associated microRNA: |
miR-146b-3p |
| Biological function: |
Represses cervical cancer progression by inhibiting proliferation, invasion and migration, promoting apoptosis, and suppressing tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-146b-3p to indirectly upregulate PAX5 (ceRNA axis). |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0000520 is suggested as a promising diagnostic and therapeutic RNA molecule of CC. |
| Description: |
hsa_circ_0000520 (circ_0000520) is down-regulated in cervical cancer and functions as a tumor suppressor. It sponges miR-146b-3p, thereby relieving miR-146b-3p-mediated repression of PAX5 and inhibiting CC cell growth, migration/invasion, while promoting apoptosis and suppressing xenograft tumor growth. |
| Confidence score: |
0.7017 |