| Expression pattern: |
UP |
| Associated gene: |
HMGA2, HNRNPK, beta-catenin, HNRNPL, E2F1, pRB |
| Associated microRNA: |
miR-490-3p |
| Biological function: |
promotes CSC-like properties, proliferation, migration, cisplatin resistance, tumor growth and metastasis; stabilizes beta-catenin |
| Molecular mechanism: |
acts as a miRNA sponge for miR-490-3p to upregulate HMGA2 in a positive feedback loop; recruits/binds HNRNPK to enhance HNRNPK-beta-catenin interaction and reduce beta-catenin degradation; HMGA2 enhances circFAM73A expression via E2F1-mediated transcription and HNRNPL-mediated circularization |
| Biological pathway or process: |
stemness (promotes); proliferation (promotes); migration (promotes); metastasis (promotes); apoptosis (inhibits); chemoresistance (promotes); Wnt/beta-catenin (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP; ChIP / ChIP-seq; In Vivo Animal Model; H&E Staining; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
High circFAM73A expression predicts poor prognosis and is an independent prognostic factor in GC patients |
| Description: |
CircFAM73A is up-regulated in gastric cancer and promotes CSC-like traits, proliferation, migration, metastasis, and cisplatin resistance. It sponges miR-490-3p to upregulate HMGA2 in a positive feedback loop, and also binds HNRNPK to stabilize beta-catenin, enhancing Wnt/beta-catenin signaling and malignancy. |
| Confidence score: |
0.8988 |