| Expression pattern: |
UP |
| Associated gene: |
E2F7 |
| Associated microRNA: |
miR-595 |
| Biological function: |
promotes proliferation and invasion; inhibits apoptosis |
| Molecular mechanism: |
circ_0109320 sponges miR-595 to upregulate E2F7 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; TUNEL; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ_0109320 expression was related to a worse overall survival and circ_0109320 was an independent prognostic variable in NSCLC; upregulated circ_0109320 level was significantly associated with TNM stages as well as lymph node metastasis of NSCLC. |
| Description: |
circ_0109320 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage/lymph node metastasis and worse overall survival. Functionally, circ_0109320 promotes NSCLC cell proliferation and invasion and inhibits apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-595, thereby increasing E2F7 expression. |
| Confidence score: |
0.7878 |