circRNA basic information
circBase ID: hsa_circ_0078607
Name: hsa_circ_SLC22A3
Synonym: circ_0078607
Host Gene: SLC22A3
Genomic location(hg19): chr6:160819010-160831878:+
Genomic location(hg38): chr6:160397978-160410846:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

ovarian cancer tissues; adjacent non-cancerous tissue samples / adjacent normal tissues
Cell lines:

SKOV3; A2780
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: Fas
Associated microRNA: miR-518a-5p
Biological function: Suppresses ovarian cancer cell proliferation and invasion and promotes apoptosis.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-518a-5p to relieve repression of Fas, increasing Fas expression.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); invasion (inhibits); apoptosis (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot
Clinical significance:

-
Description:

hsa_circ_0078607 (circ_0078607), derived from SLC22A3, is down-regulated in ovarian cancer tissues. Its overexpression suppresses ovarian cancer cell proliferation and invasion while promoting apoptosis by sponging miR-518a-5p and thereby increasing Fas expression.
Confidence score:

0.6537
Other information
Title:

Circular RNA hsa_circ_0078607 suppresses ovarian cancer progression by regulating miR-518a-5p/Fas signaling pathway.

Journal: Journal of ovarian research
Published: 2020
PubMed ID: 32503653
Study type:

combined biological and clinical study
Data availability: -
Code availability: -