| Expression pattern: |
UP |
| Associated gene: |
CD44, AGO2 |
| Associated microRNA: |
miR-520b-3p |
| Biological function: |
Promotes TNBC cell proliferation, migration, invasion, cell cycle progression, tumorigenesis and metastasis; inhibits apoptosis when upregulated. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-520b-3p to upregulate CD44, promoting EMT and TNBC progression; associated with AGO2-containing RISC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); cell cycle (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes); angiogenesis (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; ISH (In Situ Hybridization); Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; TUNEL; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Cohort Study; Clinical Sample Validation |
| Clinical significance: |
High circIFI30 expression correlates with higher histological grade/clinical stage and poor prognosis; shows diagnostic value distinguishing TNBC from noncancerous tissues. |
| Description: |
circIFI30 (hsa_circ_0005571), derived from the IFI30 gene, is upregulated in TNBC and mainly localized in the cytoplasm. It promotes TNBC proliferation, migration/invasion, EMT, tumor growth and lung metastasis by sponging miR-520b-3p to upregulate CD44. High circIFI30 is associated with advanced clinicopathological features and poorer overall survival. |
| Confidence score: |
0.8969 |