circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1as
Synonym: ciRS-7
Host Gene: CDR1-AS
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PDAC tissue; tumor microenvironment; tumor stroma; normal pancreas; pancreatitis; inflamed and fibrotic stroma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Potential marker of activated stroma or stromal activity in PDAC and pancreatitis; absent from PDAC cancer cells but abundant in tumor microenvironment.
Molecular mechanism: Spatial stromal expression pattern; no prognostic role and no mechanistic axis experimentally established in this study.
Biological pathway or process:

fibrosis (other); other pathway/process (other)
Detected method:
Q
H
S
Validation methods:

RNA-seq; RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Bioinformatics Analysis; ROC Analysis
Clinical significance:

May hold potential as a marker of activated stroma; no statistically significant prognostic role was found.
Description:

ciRS-7 was investigated mainly for spatial expression in PDAC. It was absent in PDAC cancer cells but enriched in tumor stroma and fibrotic/inflamed stromal areas, suggesting value as a stromal activity marker rather than as a cancer-cell marker.
Confidence score:

0.5267
Other information
Title:

Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Published: 2024
PubMed ID: 38724419
Study type:

combined bioinformatics and clinical study
Data availability: Supplementary Table 4; Supplementary Table 5; https://doi.org/10.1016/j.pan.2024.04.004
Code availability: -