| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-484 |
| Biological function: |
Suppresses HCC cell proliferation and increases apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge by directly binding miR-484; miR-484 mimics rescue the tumor-suppressing effect of circADAMTS13. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; Bioinformatics Analysis; RT-qPCR; divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
Low circADAMTS13 expression is associated with larger tumor size and shorter RFS; circADAMTS13 shows high diagnostic AUC for distinguishing HCC tumor tissues from healthy liver tissues. |
| Description: |
circADAMTS13 is down-regulated in HCC tumor tissues and functions as a tumor suppressor by inhibiting HCC cell proliferation and promoting apoptosis. Mechanistically, it directly binds (sponges) miR-484, and miR-484 mimics can rescue the suppressive phenotype. Clinically, low circADAMTS13 is associated with larger tumor size and shorter RFS. |
| Confidence score: |
0.8405 |