| Expression pattern: |
UP |
| Associated gene: |
IGF1 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
promotes cell proliferation, migration/invasion and metastasis; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circRUNX1 acts as a ceRNA/miRNA sponge that competitively binds miR-145-5p, relieving repression of IGF1 expression and activating IGF1 signaling to facilitate tumor growth |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circRUNX1 expression was positively related with lymph node metastasis, distant metastasis and advanced tumor-node-metastasis tumor stage; may have potential use as a prognostic indicator and therapeutic target in CRC patients |
| Description: |
circRUNX1 (hsa_circ_0002360), derived from RUNX1, is up-regulated in colorectal cancer tissues and correlates with advanced clinical features. It promotes CRC cell proliferation and migration/invasion and metastasis while inhibiting apoptosis, partly by acting as a ceRNA that sponges miR-145-5p to increase IGF1 expression/signaling. |
| Confidence score: |
0.7898 |