| Expression pattern: |
UP |
| Associated gene: |
SEMA6D, Wnt/beta-catenin signaling pathway, beta-catenin, TCF3 |
| Associated microRNA: |
miR-506-3p |
| Biological function: |
Promotes cisplatin resistance, proliferation, migration and invasion, and inhibits apoptosis in cisplatin-resistant osteosarcoma cells. |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-506-3p, thereby promoting SEMA6D expression and activating Wnt/beta-catenin signaling to enhance cisplatin resistance. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Western Blot; Annexin V/PI Flow Cytometry; Transwell Assay |
| Clinical significance: |
Higher circUBAP2 expression is associated with cisplatin-resistant osteosarcoma tissues (vs cisplatin-responsive). |
| Description: |
circUBAP2 is up-regulated in cisplatin-resistant osteosarcoma tissues/cells and promotes cisplatin resistance and malignant phenotypes. Mechanistically, circUBAP2 sponges miR-506-3p to increase SEMA6D expression and activate Wnt/beta-catenin signaling. |
| Confidence score: |
0.6521 |