| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-647, hsa-miR-532-3p, hsa-miR-526b, hsa-miR-1263, hsa-miR-432 |
| Biological function: |
Associated with BRAFV600E mutation in PTC; potential biomarker. |
| Molecular mechanism: |
Predicted to act as a miRNA sponge (ceRNA-like). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Associated with BRAFV600E mutation; AUC for BRAF mutation discrimination reported as 0.7284. Also discussed as upregulated in PTCs with microarray profiling in prior work, consistent with this study. |
| Description: |
hsa_circ_0002111 (chr8:18765448-18804898-, host gene PSD3) is up-regulated in PTC and is significantly associated with BRAFV600E mutation. It is predicted to interact with multiple miRNAs and may serve as a progression-related biomarker. |
| Confidence score: |
0.6841 |