circRNA basic information
circBase ID: -
Name: hsa_circ_TMEM132D
Synonym: -
Host Gene: TMEM132D
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumour tissues; normal tissues; thyroid tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Wnt3a
Associated microRNA: hsa-miR-4726-3p, hsa-miR-4793-3p, hsa-miR-766-3p, hsa-miR-1343, hsa-miR-1226-5p
Biological function: Associated with capsular invasion in PTC; potential biomarker for progression.
Molecular mechanism: Predicted to act as a miRNA sponge (ceRNA-like).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Associated with capsular invasion; may be a putative biomarker for progression of PTC.
Description:

chr12:129699809-129700698- (host gene TMEM132D) is up-regulated in PTC and correlates with capsular invasion, suggesting relevance to tumor progression. It is predicted to bind several miRNAs (e.g., miR-766-3p) consistent with a putative miRNA-sponge role.
Confidence score:

0.6841
Other information
Title:

Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.

Journal: Oncology reports
Published: 2020
PubMed ID: 32468074
Study type:

combined biological and clinical study
Data availability: All data generated or analysed during the present study are included in this published article.
Code availability: -