| Expression pattern: |
UP |
| Associated gene: |
UBAP2 |
| Associated microRNA: |
miR-1827 |
| Biological function: |
promotes HCC tumorigenesis by promoting proliferation and invasion and inhibiting apoptosis; promotes EMT process |
| Molecular mechanism: |
ceRNA sponging miR-1827 to increase UBAP2 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; FISH / smFISH; Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
increased hsa_circ_0003141 levels could predict worse survival outcomes in HCC patients |
| Description: |
hsa_circ_0003141 is up-regulated in hepatocellular carcinoma and acts as an oncogenic circRNA. It promotes proliferation, invasion and EMT and inhibits apoptosis by functioning as a ceRNA that sponges miR-1827 to increase UBAP2 expression, and its knockdown suppresses tumor growth in a Huh-7 xenograft model. |
| Confidence score: |
0.697 |